EvexiPEL Bioidentical Hormone Pellet Therapy
Our ApproachA Convenient, Long-Acting Option for Hormone Replacement
For some patients, remembering a daily cream, changing a patch, or maintaining a frequent injection schedule can make hormone replacement therapy feel complicated.
EvexiPEL hormone pellet therapy offers another option.
At Resilience Functional Medicine, we offer EvexiPEL bioidentical hormone pellet therapy for appropriately selected women and men as part of a personalized hormone optimization plan.
Our approach begins with understanding your symptoms, health history, laboratory findings, and goals—not simply deciding that everyone needs pellets.
What Is Hormone Pellet Therapy?
Hormone pellets are very small and are placed beneath the skin during a brief in-office procedure.
Once inserted, the pellets gradually release hormone over time, providing a longer-acting form of hormone replacement without requiring daily application or frequent injections.
EvexiPEL pellet therapy may include estradiol or testosterone, depending on your individual needs.
Other hormones, such as progesterone, may be prescribed separately when clinically appropriate.
Why Do Some Patients Choose Pellets?
Patients may consider pellet therapy because they prefer:
A longer-acting hormone delivery method
Less frequent dosing
No daily creams or gels
No patch changes
Fewer injections
An individualized treatment plan
Ongoing medical and laboratory monitoring
Convenience is one of the biggest reasons patients are interested in pellets—but it isn’t the only consideration.
Pellets cannot simply be removed or adjusted as easily as a patch, cream, or injection once they have been inserted. For this reason, careful patient selection and individualized dosing are particularly important.
A More Thoughtful Approach to
Hormone Therapy
Hormone optimization isn’t simply about increasing estrogen or testosterone.
At Resilience Functional Medicine, we also consider the factors that influence how your hormones function and how you feel—including thyroid health, insulin sensitivity, cardiovascular health, nutrition, sleep, stress, exercise, body composition, and nutrient status.
Our goal is to create a personalized strategy that supports symptom improvement while keeping your overall health at the center of the conversation.
❋ EvexiPEL for Women
Hormonal changes during perimenopause and menopause may contribute to symptoms such as:
Hot flashes and night sweats
Sleep disruption
Fatigue
Brain fog
Mood changes
Decreased libido
Changes in body composition
Loss of muscle or strength
Vaginal or genitourinary symptoms
Decreased overall sense of well-being
For appropriately selected women, pellet therapy may include estradiol and/or testosterone.
Women with a uterus who receive systemic estrogen generally also require appropriate endometrial protection, commonly with progesterone. Your complete hormone regimen will be determined individually.
❋ EvexiPEL for Men
Men may seek hormone evaluation because of:
Low energy
Decreased libido
Changes in sexual function
Loss of muscle or strength
Increased body fat
Difficulty recovering from exercise
Brain fog
Reduced motivation
Mood changes
Decreased overall vitality
For men who have been appropriately evaluated and are candidates for testosterone replacement therapy, EvexiPEL testosterone pellets provide a longer-acting alternative to topical or injectable testosterone.
Ongoing medical and laboratory monitoring remains an important part of treatment.
What to Expect
EvexiPEL is a method of hormone pellet therapy that incorporates individualized dosing, specialized provider training, and standardized pellet insertion techniques.
At Resilience Functional Medicine, pellet therapy is incorporated into a broader hormone optimization program rather than treated as a stand-alone procedure.
We consider your symptoms, laboratory findings, medical history, risk factors, previous hormone therapy, and treatment goals before determining whether pellet therapy is appropriate.
Step 1 — Comprehensive Hormone EvaluationBefore considering pellets, we start with an individualized consultation.
We review your symptoms, medical history, medications, family history, previous hormone therapy, lifestyle, and treatment goals.
Laboratory testing is used to better understand your hormone status and other factors that may be contributing to your symptoms.
Step 2 — Personalized Treatment PlanWe review your results together and discuss whether hormone replacement therapy is appropriate.
If it is, we’ll also discuss the available delivery options.
Pellets are never your only choice.
Depending on your individual situation, alternatives may include patches, creams, oral medications, injections, or other forms of hormone therapy.
Together, we determine which approach best fits your health needs, lifestyle, and preferences.
Step 3 — Pellet PlacementIf you choose pellet therapy, the procedure is performed in the office.
The skin is cleaned and numbed with local anesthetic. A very small incision is made, and the pellets are placed beneath the skin, typically in the upper buttock/hip area.
The incision is then closed and covered with a dressing.
The procedure itself is generally brief, and you’ll receive detailed aftercare instructions before leaving the office.
Step 4 — Follow-Up & MonitoringHormone therapy should never be “set it and forget it.”
Follow-up laboratory testing and symptom assessment allow us to evaluate how you are responding to treatment.
We monitor both how you feel and appropriate laboratory markers to determine whether adjustments should be considered with future treatment.
Frequently Asked Questions
-
Pellets are designed to release hormone gradually over a period of time. How long an individual treatment lasts can vary based on the hormone used, dose, metabolism, activity level, and individual response.
Your symptoms and laboratory findings help determine the appropriate timing of future treatment.
-
Response varies from person to person. Some patients notice changes sooner than others, and different symptoms may improve at different rates.
Hormone optimization is a process rather than an overnight change.
-
Local anesthetic is used to numb the area before pellet placement. Patients may experience temporary soreness, bruising, or tenderness afterward.
-
Certain activities should temporarily be limited after the procedure to allow the insertion site to heal properly.
You will receive specific post-procedure instructions regarding exercise, bathing, swimming, and care of the insertion site.
-
This is an important difference between pellets and other forms of hormone therapy.
Once pellets have been inserted, the dose cannot be quickly increased or decreased in the same way a patch, cream, or injection can be adjusted.
This is one reason we take patient selection, initial dosing, laboratory testing, and follow-up seriously.
Future pellet doses can be modified based on your response.
-
There isn’t one form of hormone therapy that is best for everyone.
Pellets offer convenience and longer intervals between treatments, while patches, creams, and injections offer greater flexibility for dose adjustments.
We will discuss the advantages and limitations of each option and help you decide which approach makes the most sense for you.
-
Hormone pellets used in compounded hormone therapy are not FDA-approved drug products. Compounded medications are prepared for individual patients based on a prescription from a licensed healthcare provider.
We believe patients should understand both the potential benefits and limitations of any treatment before deciding whether it is right for them.